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  5. πŸ“ Introduction To The Human Gut Microbiota
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  4. πŸ“ Introduction To The Human Gut Microbiota

πŸ“ Introduction To The Human Gut Microbiota

The human gastrointestinal (GI) tract represents one of the largest interfaces (250–400 m ) between the host, environmental factors and antigens in the human body. In an average life time, around 60 tonnes of food pass through the human GI tract, along with an abundance of microorganisms from the environment which impose a huge threat on gut integrity [1]. The collection of bacteria, archaea and eukarya colonising the GI tract is termed the β€˜gut microbiota’ and has co-evolved with the host over thousands of years to form an intricate and mutually beneficial relationship [2,3]. The number of microorganisms inhabiting the GI tract has been estimated to exceed 10 , which encompasses ꔆ10 times more bacterial cells than the number of human cells and over 100 times the amount of genomic content (microbiome) as the human genome [2,4]. However, a recently revised estimate has suggested that the ratio of human:bacterial cells is actually closer to 1:1 [5]. As a result of the vast number of bacterial cells in the body, the host and the microorganisms inhabiting it are often referred to as a β€˜superorganism’

Updated on March 17, 2020

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