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  5. 📝 CHRONICALLY INCREASED ACTIVITY OF THE SYMPATHETIC NERVOUS SYSTEM: OUR DIET-RELATED “EVOLUTIONARY” INHERITANCE

📝 CHRONICALLY INCREASED ACTIVITY OF THE SYMPATHETIC NERVOUS SYSTEM: OUR DIET-RELATED “EVOLUTIONARY” INHERITANCE

The importance of sympathetic nervous system (SNS) activity in the pathogenesis of cardiovascular disease (CVD), like essential hypertension, atherosclerosis and age related arterial wall thickening, heart failure and ventricular arrhythmias is well established (1-5). The SNS has been implicated in the pathogenesis of atherosclerosis through its ability to induce vascular smooth muscle cell proliferation (3, 5, 6), to directly activate the reninangiotensin- system (RAS) (7), and to impair endothelial function (8), key factors in the atherogenic process (9). SNS hyperactivity and activation of the RAS also are key factors in the pathogenesis of essential hypertension (10, 11).This is corroborated by the (12) and antihypertensive (13) effects of beta-blockade.

Updated on March 17, 2020

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