Type 2 diabetes mellitus (T2D) is a serious global problem that is closely related to the rise in obesity. Insulin resistance plays a central role in the pathogenesis of T2D  and is an early marker for the disease. Therefore, it is imperative to have a simple method to identify insulin resistance in the early stages in order to implement preventative measures. The gold standard test for insulin resistance is the hyperinsulinemic euglycemic clamp (HIEC); however, this technique is cumbersome and is restricted for research. Other methods, such as the minimal model approximation of the metabolism of glucose (MMAMG) [2, 3] and homeostasis model assessment to estimate insulin resistance (HOMA-IR), can be also used; however, they are indirect derivatives computed from fasting insulin and glucose determinations….
Updated on June 26, 2020