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πŸ“ Glycolysis At 75: Is It Time To Tweak The First Elucidated Metabolic Pathway In History?

The sequence of the glycolytic enzymatic reactions responsible for the breakdown of glucose into two trioses and further into pyruvate or lactate was elucidated in 1940. For over seven decades it has been taught precisely the way that sequence was first described by Embden, Meyerhof and Parnas. Accordingly, two different glycolytic outcomes were proposed; the aerobic one with pyruvate as the final product, and the anaerobic one, identical to aerobic glycolysis except for one additional step, the reduction of pyruvate to lactate. While pyruvate has been presented as the mitochondrial substrate of the tricarboxylic acid cycle, lactate has regularly been vilified as a useless and frequently toxic end product of anaerobic glycolysis. Several studies in the 1980s have shown that both muscle and brain tissues are capable of oxidizing and utilizing lactate as an energy substrate, thus challenging the monocarboxylate’s ill reputation…..

Updated on July 13, 2020

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