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  3. πŸ“ Enhanced Protein Translation Underlies Improved Metabolic And Physical Adaptations To Different Exercise Training Modes In Young And Old Humans

πŸ“ Enhanced Protein Translation Underlies Improved Metabolic And Physical Adaptations To Different Exercise Training Modes In Young And Old Humans

The molecular transducers of benefits from differentexercise modalities remain incompletely defined.Here we report that 12 weeks of high-intensity aero-bic interval (HIIT), resistance (RT), and combined ex-ercise training enhanced insulin sensitivity and leanmass, but only HIIT and combined training improvedaerobic capacity and skeletal muscle mitochondrialrespiration. HIIT revealed a more robust increasein gene transcripts than other exercise modalities,particularly in older adults, although little overlapwith corresponding individual protein abundancewas noted. HIIT reversed many age-related differ-ences in the proteome, particularly of mitochondrialproteins in concert with increased mitochondrial pro-tein synthesis. Both RT and HIIT enhanced proteinsinvolved in translational machinery irrespective ofage. Only small changes of methylation of DNA pro-moter regions were observed. We provide evidencefor predominant exercise regulation at the transla-tional level, enhancing translational capacity andproteome abundance to explain phenotypic gainsin muscle mitochondrial function and hypertrophyin all ages

Updated on June 14, 2020

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