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๐Ÿ“ ATP-Sensitive Potassium Channel-Mediated Lactate Effect On Orexin Neurons: Implications For Brain Energetics During Arousal

The brain, although comprising only 2% of body weight, is responsible for 25% of total body glucose utilization, necessitating a continuous supply from the periphery (Magistretti et al., 1995). This is thought to be ensured by the glucose homeostatic mechanism involving โ€œglucosensorsโ€ that exist in the hypothalamus and brainstem (Levin et al., 2004; Marty et al., 2007). Glucosensing neurons are excited [glucose excited (GE)] or inhibited [glucose inhibited (GI)] by extracellular glucose and induce appropriate counterregulatory responses to restore glucose homeostasis (Levin, 2001). Glucosensing in certain GE and GI neurons depends on glucokinase, a critical enzyme that catalyzes glycolysis (Lynch et al., 2000; Dunn-Meynell et al., 2002; Kang et al., 2004; Balfour et al., 2006), suggesting that glucose metabolism is directly involved in their electrophysiological response to glucose.

Updated on October 14, 2020

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